Recent Publications

Lenk, GM, Jafar-Nejad P, Hill SF, Huffman L, Smolen C, Wagnon JL, Petit, H, Giger, R, Rigo F, Meisler MH (2020) Antisense oligonucleotide therapy delays seizure onset and extends survival in a mouse model of SCN8A encephalopathy. Ann. Neurol. 87:339-346.

Yu, W, Hill SF, Xenakis JG, Pardo-Manuel de Villena, F, Wagon JL and Meisler MH. (2020) Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse. Epilepsia 61:2847-2856.

Bunton-Stasyshyn RKA, Wagnon JL, Wengert ER, Barker BS, Faulkner A, Wagley PK, Bhatia K, Jones JM, Maniaci MR, Parent JM, Goodkin HP, Patel MK, Meisler MH (2019) Prominent role of forebrain excitatory neurons in SCN8A encephalopathy. Brain 142: 362-375.

Solé L, Wagnon JL, Akin AJ, Meisler, MH and Tamkun MM (2019) The MAP1B binding domain of Nav1.6 is required for stable expression at the axon initial segment. J. Neurosci 39:4238-4251, 2019.

Wengert ER, Cathrine E. Tronhjem CE, Jacy L. Wagnon JL, Katrine M Johannesen KM, Petit H, Krey I, Anusha I, Saga U, Panchal PS, Strohm SM, Lange J, Kamphausen SB, Rubboli, G Lemke JR, Gardella E,PatelMK, Meisler MH, Møller RS. (2019) Biallelic inherited variants of SCN8A are a rare cause of epileptic encephalopathy. Epilepsia 60:2277-2285.

Wagnon JL, Barker BS, Hounshell, Haaxma C, Shealy A, Moss T, Parikh S, Messer, RD, Patel MK and Meisler MH (2015a) Pathogenic mechanisms of recurrent epileptogenic mutations of SCN8A in epileptic encephalopathy. Annals of Clinical and Translational Neurology. DOI 10.1002/acn3.276.

Wagnon JL, Korn MJ, Parent R, Tarpey TA, Jones JM, Hammer MF, Murphy GG, Parent JM and Meisler MH (2015b) Convulsive seizures and SUDEP in a mouse model of SCN8A related epileptic encephalopathy, Human Molec.Genet. 24:506-516.

Recent Reviews

Meisler MH, Hill SF and Xu W, (2021) Sodium channelopathies: neurodevelopmental aspects and epilepsy. Nature Reviews Neuroscience, in press.

Meisler, MH (2019) SCN8A Encephalopathy: Mechanisms and Models. (2019) Epilepsia 60 Suppl 3:S86-S91. doi: 10.1111/epi.14703. PMID: 31904118

Meisler MH, Helman G, Hammer MF, Fureman BE, Gaillard WD, Goldin AL, Hirose S, Ishii A, Kroner BL, Lossin C, Mefford HC, Parent JM, Patel M, Schreiber J, Stewart R, Whittemore V, Wilcox K, Wagnon JL, Pearl PL, Vanderver A, Scheffer IE (2016) SCN8A Encephalopathy: Research Progress and Prospects. Epilepsia 57:1027-35